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GLP-1 RAs regulate immune cell signaling, suppress proinflammatory cytokines (including tumor necrosis factor alpha (TNF), interleukin-6 (IL-6), and interleukin-1 beta (IL-1)), enhance anti-inflammatory cytokines (interleukin-10- (IL-10)), and decrease reactive oxygen species
Le Roux CW, Astrup A, Fujioka K, Greenway F, Lau DC, Van Gaal L, Ortiz RV, Wilding JP, Skjth TV, Manning LS
Given the substantial differences in pharmacokinetics, duration of receptor exposure, effects on gastric emptying, and weight-loss efficacy among individual compounds, drug-specific microbiota effects are highly plausible but currently masked by underpowered, heterogeneous study designs
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