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Male patients must also use effective contraception to prevent Accutane transmission through the semen

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For example, a study on asiatic acid (AA) demonstrated that AA significantly inhibits oxidative stress, reduces cytokine and chemokine production, and decreases inflammatory cascade through inhibition of NLRP3 inflammasome and NF-B pathway, similar to mechanisms observed with other plant antioxidants such as curcumin and resveratrol in suppressing NF-B activation

The fetal distress resolved hours later, and prior to delivery of the healthy infant