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Unfortunately, with the possible exception of LPS and I-FABP, validation of these assays against standard permeability measurements and proper clinical validation studies in large groups of patients are missing and can therefore not be recommended to replace the direct permeability tests described above

A phase 2/3 randomized clinical trial followed by an open-label extension to evaluate the effectiveness of elamipretide in Barth syndrome, a genetic disorder of mitochondrial cardiolipin metabolism

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Although the studys scale was small, the potential implications are significant, paving a new pathway for those seeking relief from interstitial cystitis