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Acknowledgements DVDS gratefully acknowledges the Research Foundation Flanders (FWO, 3G012609) and Ghent University (BOF-GOA2018) for generous support, and acknowledges the Francqui Foundation for awarding her a Collen-Francqui Research Professorship (STI.DIV.2022.0014.01)
Zofran (Ondansetron) is a medication that is used to treat nausea and vomiting and is used at Reflections Wellness Spa to treat these symptoms in patients taking Semaglutide and Tirzepatide
Pharmacokinetic analysis revealed it to be orally active with significantly increased metabolic stability, exhibiting a plasma half-life of 335.5 minutes, allowing for prolonged systemic availability [2]
Mechanism of Action: Selective muscarinic agonist, resistant to hydrolysis by different cholinesterase isoenzymes The same backbone structure as acetylcholine, but with a methyl side group (Figure 1), which is responsible for its selectivity for muscarinic vs nicotinic receptors (Vardanyan & Hruby, 2006)
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