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Business development and portfolio prioritization decisions are increasingly factoring in this IRA-derived clock differential

March 02, 2012

In cell-based assays retatrutide is deliberately unbalanced relative to the native hormones about 0.4 times as active at the GLP-1 receptor, 0.3 times as active at the glucagon receptor and roughly 8.9 times as active at the GIP receptor so GIP signalling carries the most weight while the glucagon arm stays measured [6]

A compound that is clean enough for a binding assay is not automatically clean enough for a quantitative cell-based readout where a co-eluting impurity could carry activity of its own