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PA most likely prevented activation of the pro-inflammatory factors and reduced LPS/D-Gal-induced liver injury by enhancing the zinc finger E-box-binding homeobox 2 expression level, and consequently, blocking activation of the NF-B signaling pathway in the liver (Yang et al., 2021a)

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The peptide appears to act through direct interaction with adipocytes (fat cells), potentially involving activation of hormone-sensitive lipase (HSL) and modulation of -adrenergic receptor signaling pathways

& Pirofski, L