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Hyperglycaemia progressively impairs these transporters, accelerating beta-cell apoptosis and microvascular complications

A growing body of evidence positions Alzheimer's disease as fundamentally a disorder of impaired brain energy metabolism, one in which neurons progressively lose the ability to utilize glucose efficiently, creating an energetic crisis that precedes structural damage by years or even decades

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99 However, its diagnostic utility can be significantly limited by factors such as intestinal gas or obesity