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The screening identified quinoliniums as a promising scaffold, and 5-Amino-1MQ emerged as one of the most active compounds with an IC 50 of approximately 1.2 M under the biochemical assay conditions used
Some portion of intranasally administered peptides may reach the central nervous system through the olfactory pathway, bypassing the blood-brain barrier
it is the mechanism by which the 28-day limit is enforced in practice
Nevertheless, extending the half-life of BPC157 and further improving its pharmacokinetic characteristics are important directions for the future development of this drug
