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reducing the use of auxiliary or protecting groups Landscapes Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA) Abstract (BPC 157)4--4--2--DIC/HOBtDIC/HOAtBOP/HOBtBOP/HOAtHBTU/HOBtHBTU/HOAtHATU/HOBtHATU/HOAtHCTU/HOBt(BPC 157)BPC 157C18(C8)(BPC 157)(BPC 157)(BPC 157)The invention discloses a method for synthesizing a body-protecting polypeptide (BPC 157 peptide), which comprises using trityl chloromethyl resin, 4-methyl-trityl chloromethyl resin, 4-methoxy-trityl chloromethyl Any one of resin, 2-chloro-trityl chloromethyl resin or Wang resin is a starting material, with DIC/HOBt or DIC/HOAt or BOP/HOBt or BOP/HOAt or HBTU/HOBt or HBTU/HOAt or One of HATU/HOBt or HATU/HOAt or HCTU/HOBt is used as a condensing agent to carry out the peptide-grafting reaction to obtain the resin for protecting the body's protective polypeptide (BPC 157 peptide), and then simultaneously remove the side chain protecting group and cut the peptide
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Klicek R, et al
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