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This less conserved domain, compared to the N-terminal domain, notably contains a well-conserved N-capping box (S/TXXD) including the S/T N-cap residue (Figure 3A) and a hydrophobic staple motif located at the N-terminal part of 6 helix
Scientific studies have shown that GLP-1 receptor agonists like Ozempic can bind to cells and receptors that produce glucagon and signal them to cease production when insulin levels are high
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