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Weight gain is associated with reduced striatal response to palatable food
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Most K cells express PC1/3, which cleaves proGIP at Arg65, resulting in the biologically active GIP(142) (Ugleholdt et al., 2006) and stored in secretory granules (450 nm) (Meier et al., 2004a), GIP promotes nutrient-stimulated insulin secretion and increases glucagon secretion in the fasted state but not in patients with type 2 diabetes ( The physiological concentrations of the peptide hormones GIP, GLP-1, and GLP-2, are tightly controlled by the nutrient-sensing abilities of their respective enteroendocrine cells
For normal constipation, the recommendation is to see a doctor if the symptoms last longer than three weeks, if they make it difficult to perform daily activities, if there is blood involved in any way, or if you have stomach pain that refuses to go away
