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21 Mechanistically, the presence of GLP-1 receptors in the retina raises the possibility of a direct toxic effect of the GLP-1/GIP agonists leading to the observed retinopathy progression

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Ifinatamab deruxtecan (DS-7300a, I-DXd), a B7-H3-targeting ADC with a potent DNA topoisomerase I inhibitor, showed promising results in 19 patients with heavily pretreated SCLC, achieving an ORR of 58%