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( S )-dHTC1 showed greater antiproliferative effects than ENL/AF9 YEATS domain inhibitors in wild-type (WT) MV4;11 cells but not in CRBN-deficient cells, demonstrating that ENL degradation is more effective than inhibition (Fig
One significant positive in this study is that they also used laser Doppler scanning (recovery of blood flow in the ischemic muscle) to indicate the promotion of angiogenesis alongside Western blot and real-time PCR for the expression of VEGFR2
This multi-target approach may explain why BPC-157 seems effective for conditions that resist single-mechanism treatments
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