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However, current mechanistic understanding is derived almost entirely from preclinical and non-ARD clinical data
Despite the absence of a statistically significant doseresponse relationship observed in this analysis, clinical decision-making should consider that absorption efficiencyrather than absolute dosagemay be the limiting factor
How this option is evaluated
The titration ramp for cagrilintide takes 16 weeks even at the conservative cadence, which extends the side-effect runway
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