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This is a separate risk from whether the compound works, and it applies even to peptides with a plausible mechanism

Figure I and II adapted from Sackman et al

Front Immunol 10:115 Rey-Campos M, Moreira R, Valenzuela-Muoz V, Gallardo-Escrate C, Novoa B, Figueras A (2019b) High individual variability in the transcriptomic response of Mediterranean mussels to Vibrio reveals the involvement of myticins in tissue injury