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The GI side effects should not be discounted and need to be considered along with cost when considering using a drug like tirzepatide, he added, but in those who can get access to the drug and take it, theres substantial benefits. The number of patients living with CVD who also have obesity and other comorbidities is increasing, Sattar noted

Your body doesnt put on extra pounds just because you eat too many calories, or the wrong kinds of calories, or too much saturated fat, or any of the dozens of other weight loss theories behind crash diets

If additional glycemic control is needed after at least 4 weeks on a 0.5 mg dose, the dosage may be increased to 1 mg or 2 mg once weekly

The crypt damage scoring indicates a significant reduction in whole crypt damage in the PYY group (38% vs