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At a 4mg/mL concentration (10mg vial in 2.5mL BAC water), a 12mg weekly dose requires a 3mL injection volume which exceeds the practical limit for a single subcutaneous injection into most sites
That is why exercise is important even if you are already on GLP-1 RAs
According to clinical trials published in the New England Journal of Medicine, Zepbound shows slightly higher rates of GI effects at higher doses: nausea (31-33%), diarrhea (21-23%), and vomiting (12-20%)
Semaglutide for Weight Control Although Semaglutide was originally created to help patients with type 2 diabetes control their blood sugar, in 2021 the FDA approved the drug for long-term weight loss in non-diabetic patients
