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Electrophysiological experiments in frontal cortical slices from D 4 R knockout mice showed an increased ability of a D 4 R agonist to suppress network bursts and NMDA receptor-mediated excitatory postsynaptic currents from P neurons after viral transduction of human D 4.7 R, as compared with human D 4.4 R receptor cDNA (49, 50)
46 In 2018, a gene therapy employing an allogeneic expression strategy was tested in a clinical trial for patients with LHON, demonstrating both safety and good tolerability
Caffeine may be a confounding factor in some studies
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