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When weight loss occurs gradually, the skin's fibroblasts can continue producing collagen and elastin, allowing it to retract more effectively, but with rapid or significant weight loss, the skin's ability to contract is overwhelmed, leading to lax tissue and an inability to snap back

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Tan IIA induced activation of the GSH system to attenuate cardiac oxidative stress and restrain the increase in serum myocardial enzymes, thus relieving the extent of myocardial damage [154, 155]