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where the Tri-GalNAc moiety is attached to a target-protein ligand to direct extracellular and membrane proteins to the lysosome for degradation via ASGPR-mediated endocytosis in hepatocytes
C56H65N3O24 / 1164
/ α-GalNAc-Butyl-Carboxy Methyl Ester / α-GalNAc-C4-COOMe
/ α-D-GalNAc-Ser-NH-Biotin / Biotinyl Tn Antigen (Serine)
PE131000: α-GalNAc-PEG3-Alkyne Pack Size:100 mg where the Tri-GalNAc moiety isC17H29NO9 391. 41 An D N acetylgalactosamine (GalNAc) ligand equipped with a terminal alkyne through a hydrophilic PEG3 spacer. The alkyne couples to azide functionalized partners via copper catalyzed azide alkyne cycloaddition (CuAAC), forming stable 1,2,3 triazole linkages. This compound enables the construction of hepatocyte targeted therapeutics and research tools that exploit the asialoglycoprotein receptor (ASGPR), which is highly expressed on
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