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Description

Newer guidelines require more info on metabolite toxicity and PK if the metabolite is considered a major metabolite by FDA guidelines

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Nature 469 , 498503 (2011)

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A randomized placebo-controlled pilot study of N-acetylcysteine in youth with autism spectrum disorder

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The molecular gutliver signaling, we substantially revised the manuscript with detailed discussions of key pathways: TLR4/NF-B, MAPK signaling, tight junction regulation, microbial metabolite signaling (e.g., SCFAs), and cytokine cascades

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