retatrutide phase 2 trial obesity nejm 2023 π Semaglutide 2.4mg: β13.7% weight loss (SURMOUNT-5 head-to-head), π Tirzepatide 15mg: β20.2% weight loss (same trial, 2025), π 12mg: β28.7% weight loss (TRIUMPH-4, 3, Dec Retatrutide Phase 3: TRIUMPH Program
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