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In rare cases, rapid improvement in glycaemic control can lead to a phenomenon sometimes called 'insulin oedema'
Efficacy and safety of saxagliptin combination therapy in US patients with type 2 diabetes
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Under physiological conditions, GIP enhances adipose tissue insulin sensitivity and stimulates adiponectin secretion, thereby indirectly activating hepatic AMPK and FGF21 pathways that promote fatty-acid oxidation and improve metabolic flexibility
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