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Quality assessment The included studies were assessed for quality using version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2) [20]
Genetic ablation of CB1R specifically in macrophages or in beta cells prevents islet inflammation in diet-induced obesity [7, 10]
6 Nara Aline Costa, et al
Practical Mitigation Strategies Start low and increase it gradually to minimise GI upsettitrate semaglutide from 0.25 mg weekly, increasing gradually every 4 weeks
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