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Lower initial exposure may reduce early side effects, and improved tolerability can make it easier for patients to remain on therapy long enough to evaluate its benefits
Without adequate protein, this ratio shifts unfavorably toward muscle loss
Retatrutide is an investigational medication not approved by the FDA as of April 2026
If side effects are intolerable at a particular dose level, clinicians may recommend maintaining that dose for an additional 4 weeks before escalating, or reducing to the previous dose temporarily
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