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In whole-cell current clamp experiments, hyperpolarizing or depolarizing current pulses (500 ms, from 10 to 30 pA in 5-pA steps) were injected into neurons to determine input resistances or trigger action potentials

Similarly, 2,2-bipyridine, a fast-acting iron chelator that acts similarly to DFO, protects LAMP-2 knockdown cells from tributyl phosphate (THP)-induced cell death in human RPE-19 cells and in primary fetal retinal pigment epithelium (52)

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Many cardiometabolic benefits, such as blood pressure and cholesterol improvements, drifted back toward baseline