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Therefore, while existing evidence supports low local toxicity, comprehensive in vitro and in vivo immunogenicity testing remains advisable prior to clinical translation [71, 191]
155 A meta-analysis of trials in elderly subjects with mild cognitive impairment found B12 plus folate lowered homocysteine and improved cognitive function more than either nutrient alone
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This stress-induced ubiquitination did not reflect nonspecific degradation of damaged proteins but rather a regulatory process involving stress granule disassembly and reactivation of cellular homeostasis after stress removal [42]
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