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Some human-longevity claims originate from studies of Epithalamin rather than Epitalon
Sci China Life Sci (2020) 63:86674
Nrf2, a member of the capncollar family of basic regionleucine zipper transcription factors involved in transcription of antioxidant genes in response to xenobiotic stress, is also a critical regulator of cellular oxidative stress in sepsis (Kolls, 2006) and a regulator of exacerbated proinflammatory cytokine release (cytokine storm) and loss of T lymphocytes (leukopenia) that characterize the most aggressive presentation of SARS-CoV-2-mediated COVID-19 infection (Kobayashi et al., 2016
p16 ink4a is a cyclin-dependent kinase inhibitor that activates retinoblastoma-associated protein and induces cellular senescence [64], while the loss of nuclear HMGB-1 is considered a senescence biomarker [16, 44]
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