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GLP-1R is abundantly present in the pancreatic beta cells, gut, and the CNS, including the cerebral cortex, hippocampus, hypothalamus, thalamus, caudate-putamen and globus pallidum (89, 106108)
A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models
The definition of low certainty is that our confidence in the effect estimate is limited (the true effect may be substantially different from the estimate of the effect)
The study population was also primarily White and female, so future research will need to include more diverse groups of patients
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