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doi: 10.3389/fendo.2023.1215356 Received 01 May 2023 Accepted 25 September 2023 Published 10 October 2023 Volume 14 - 2023 Edited by Bert B

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3 Roles and response mechanisms of heat shockrelated proteins in the pathogenesis of male infertility 3.1 Composition and functional basis of the HSF/HSP system in dynamic stress responses Under heat stress, the testicular cells activate a series of protective responses, among which heat shock factors (HSFs) and heat shock proteins (HSPs) play central roles (Widlak and Vydra, 2017)