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In IBD, acetyl-L-carnitine improves immune tolerance by decreasing the ratio of Th17 cells and macrophages.[ref] Inborn errors of metabolism: Genetic mutations and carnitine Genetic mutations in the genes involved in the carnitine shuttle can cause inborn errors of metabolism for long-chain fatty acids
PlexusDx recommends genetic testing and baseline labs before attempting dual therapy, along with conservative dosing and frequent follow-up
The SURPASS-CVOT trial examining tirzepatide's cardiovascular outcomes is ongoing, and results are expected to inform future labeling
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