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For example, synergistic sonodynamic immunotherapy mediated by a polymer nanosome-lysosome-targeting chimera nano-LYTAC can degrade membrane proteins on M2-type macrophages and produce sonodynamic effects, and can effectively reprograms the tumor immunosuppressive microenvironment by inhibiting the functions of M2 TAMs and Tregs, as well as promoting DCs maturation and tumor infiltration of effector T cells, thereby inhibiting tumor growth and metastasis (220)