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It is important to distinguish between a mild, transient burning sensation lasting seconds to minuteswhich is generally benignand more concerning signs such as persistent pain, spreading redness, swelling, or warmth that might indicate infection or allergic reaction

Interestingly, estrogen stimulation of breast cancer cells that do not express BRCA1 and, as a result, suffer from high intracellular ROS levels rescues NRF2 transcription, enhancing the survival of these cancer cells 64

These findings carry clinical significance for obesity management