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In a pivotal Phase 2 randomized controlled trial by ONeil et al, semaglutide demonstrated significantly greater reductions in body weight compared to liraglutide (13.8% to 11.2% vs 7.8%) over 52 weeks, with up to 65% of patients achieving 10% weight loss

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Humans express a second BDH gene, BDH2, whose encoded protein is only 20% identical to the BDH1 encoded protein

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