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Anticipate mixed results because of genetic and physiological variability
If it does affect the shape, that effect is done, and then you have another variant and another variant, it's altering its shape in different ways
Its also required for cells to divide and grow appropriately
Although we may not have sufficient power to detect significant changes in our secondary outcomes (tau PET, MRIs, CSF AD biomarkers and cognition), including a nine-month follow-up will help provide preliminary evidence of successful modification of disease trajectory over a one-year period
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