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The enhanced absorption of semaglutide is thought to be due to the indirect action of SNAC, which is incorporated into the lipid membrane of local gastric cells and fluidizes the plasma membrane of the gastric epithelium (a solid-to-fluid structural transition), allowing transcellular passage of semaglutide [3, 56]

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However, reformulation is slow, and experts state that the reasons are starting to look less like a technology problem and more like a framing one