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Treatment with GLP-1RAs can provide supraphysiologic and sustained stimulation of the GLP-1 receptor
Most people using semaglutide or tirzepatide at home describe it as less uncomfortable than a flu shot
It has a neuroendocrine pathway independent of the GLP-1 receptors, working by stimulating melanocortin-4 receptors (MC4R) to reduce hunger and increase basal metabolic rate
CT-388 (red) sits on the 1:1 diagonal, indicating balanced engagement of both GLP-1R and GIPR (EC50 = 0.030 nM for both)
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