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In 2024, semaglutide 2.4 mg (Wegovy) received FDA approval for cardiovascular risk reduction in adults with established cardiovascular disease and either overweight or obesity, based on the SELECT trial
Small increases above a person's typical weekly routine (~30 min) showed little impact, but larger deviations were associated with elevated HR and persistently lower HRV suggesting recovery tolerance narrows after GLP initiation
The sublingual route of administration is often thought to increase bioavailability
The relatively short washing period (20 min) between the two stimulations could explain this, as molecular sensors involved may have been saturated or desensitized by the first stimulation by the time of the second stimulation
