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GLP-1 is a large protein hormone that cannot be absorbed through the skin
Consequently, in phase 2 and 3 trials with oral semaglutide, the recommendation was to administer oral semaglutide in the fasting state with up to 120 mL water and wait at least 30 min post-dose before eating or taking any other oral medications
This can help to mimic insulin production which reduces hyperglycemia in patients with type 2 diabetes
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