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For example, rat TDSCs treated with IGF-1 (1, 10, and 100 ng/mL) for 28 days exhibited the increased expression of tendon-specific marker (SCX) and significantly decreased expression of chondrogenic and osteogenic marker (collagen type II) (Holladay et al., 2016)

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People who are otherwise healthy may be less willing to accept these potentially serious adverse events." GLP-1 agonists were originally developed for managing Type 2 diabetes, but exploded in popularity over the past decade as an off-label weight-loss tool, reaching approximately 40 million prescriptions in the U.S

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