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However, the FDA has not approved this medication in the United States [11]

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The ectopic expression of mutant variants of PTEN, which are either devoid of lipid phosphatase (G129E) or both lipid and protein phosphatase (C124S) activity, results in a reduction in doxorubicin sensitivity in MCF-7 cells with wild-type PTEN while simultaneously increasing sensitivity to the mTOR inhibitor, rapamycin [37]

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