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In the triple therapy cohort receiving metformin, SGLT2-i, and GLP-1RA, overbasalization declined from 62.5 to 17.5%, and 42.5% of patients were able to stop insulin entirely, reinforcing the additive benefits of combination therapy [44]
Most patients don't want to eat that much because tirzepatide's appetite suppression kicks in, but listening to your fullness signals and eating slowly helps prevent side effects
Malhotra 2024
But the method of administration plays a crucial role in how reliably these benefits are achieved
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