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Analysis of tissue samples found that GLP-1 receptor proteins were most numerous in the pancreas, consistent with the drugs' known benefits in diabetes, but the heart had the second-highest concentration
Therefore, SCFAs deficiency may represent a contributing factor to PCOS symptomatology, potentially through multiple interconnected mechanisms including exacerbating ovarian inflammation, impairing follicular maturation, aggravating IR, and promoting follicular atresia via direct suppression of glucose uptake in granulosa cells
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