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The appetite-suppressing effects mediated through GLP-1 and GIP receptor activation diminish as the medication clears from the system, with most of the drug eliminated within 3-4 weeks (approximately 4-5 half-lives)
Commonly discussed side effects of semaglutide may include nausea, vomiting, diarrhea, constipation, abdominal discomfort, reduced appetite, and indigestion
over 24 weeks it significantly reduced the proportion of participants who gained weight
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