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For instance, in NSCLC, treatment with first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) often leads to the development of the EGFR T790M mutation, while third-generation inhibitors subsequently select for the C797S mutation, both of which confer resistance

**Rare Blood Disorders**: In extremely rare cases, high doses of glutathione may lead to blood disorders such as hemolysis, especially in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency

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The tripeptide upregulates collagen I and III synthesis, stimulates angiogenesis via VEGF pathways, and modulates the NF-kB inflammatory cascade toward resolution rather than amplification