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Device Flushing: Suitable for flushing IV lines and medical devices to maintain patency
The break is not required for safety or receptor resensitization, but it allows for reassessment and prevents indefinite use of a compound with limited long-term human data
Exposed hydrophobic regions of misfolded proteins can recruit HSP70 and HSP90, thereby releasing HSF1 from inhibitory chaperone complexes and initiating the heat shock response (Rutledge et al., 2022
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