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Experimental evidence suggests that caspase-3 can proteolytically degrade the N-terminal cytoplasmic domain of AE1 [93, 94]
Nonetheless, semaglutide facilitated maintaining a stable weight of 117 kg (BMI 54.5 kg/m 2 , WC 128 cm, WHR 0.96), without further weight regain and her HbA1c remained stable at 5.8%
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