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These effects are dose-dependent and require systemic exposure to the medication

This structural selectivity means AOD-9604 cannot trigger the intracellular signaling cascades normally initiated by growth hormone receptor activation

The protocol design, with its four-week intervals between escalations, intentionally allows time for this adaptation

For lipid peroxidation level, Cells were treated with the fluorescent dye BODIPY 581/591 C11 (D3861, Thermofisher Scientific), which inserts into lipid membranes and allows for quantitative assessment of oxidized versus non-oxidized lipids by fluorescing green or red, respectively