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Obesity classes (adult, per NHLBI): Class 1 obesity: BMI 30.034.9 Class 2 obesity: BMI 35.039.9 Class 3 obesity (morbid/severe): BMI 40.0 Pediatric obesity is defined differently
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10.1093/ibd/izad283 10 ChenX.ZhangM.ZhouF.GuZ.LiY.YuT.et al (2023b)
Phase 1a studies in healthy volunteers, published in Diabetes, Obesity and Metabolism in 2023, established the compound's single-dose and multiple-dose pharmacokinetics, confirming a half-life supportive of once-daily dosing, a favorable food-effect profile, and dose-proportional exposure across the tested range
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