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Moreover, CNS GIPR KO and mGIPR-Ab/GLP-1 treatment of wild-type mice both result in reduced activity in pathways associated with immune function, particularly neutrophil degranulation, suggesting that decreased CNS GIPR signalling might reduce obesity-associated inflammation 47,48,49
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Anaesthetic management strategies may include: Point-of-care gastric ultrasound to assess stomach contents before proceeding with anaesthesia Use of rapid sequence induction techniques with cricoid pressure to minimise aspiration risk Clear-fluid diet for 24 hours before surgery in higher-risk patients Consideration of regional or local anaesthesia alternatives when appropriate In some cases, postponement of elective surgery if significant gastric contents are identified There is no evidence that GLP-1 medications affect the efficacy of anaesthetic drugs, alter consciousness levels, or interfere with post-operative recovery in ways unrelated to aspiration risk
Enhancing cognitive functioning in the elderly: multicomponent vs resistance training
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